Intermittent hypoxia produces Alzheimer disease?
نویسندگان
چکیده
منابع مشابه
Intermittent hypoxia produces Alzheimer disease?
Alzheimer disease (AD) is the most common type of dementia, and the neuropathological hallmarks of AD are depositions of amyloid β protein (Aβ) (senile plaques) and hyperphosphorylated tau (neurofibrillary tangles). Accumulating evidence have indicated that aging is the major risk factor of AD, however, lack of suitable models has complicated studying the relationship between aging and AD. In o...
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Increasing evidence indicates that stimulating hippocampal neurogenesis could provide novel avenues for the treatment of depression, and recent studies have shown that in vitro neurogenesis is enhanced by hypoxia. The aim of this study was to investigate the potential regulatory capacity of an intermittent hypobaric hypoxia (IH) regimen on hippocampal neurogenesis and its possible antidepressan...
متن کاملIntermittent hypoxia and neurorehabilitation.
In recent years, it has become clear that brief, repeated presentations of hypoxia [i.e., acute intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in certain cases of neurologic dysfunction. This hypothesis derives from a series of studies in animal models and human subjects performed over the past 35 yr. In 1980, Millhorn et al. (Millhorn DE, Eldridge...
متن کاملChronic intermittent hypoxia induces atherosclerosis.
RATIONALE Obstructive sleep apnea, a condition leading to chronic intermittent hypoxia (CIH), is associated with hyperlipidemia, atherosclerosis, and a high cardiovascular risk. A causal link between obstructive sleep apnea and atherosclerosis has not been established. OBJECTIVES The objective of the present study was to examine whether CIH may induce atherosclerosis in C57BL/6J mice. METHO...
متن کاملIntermittent hypoxia: cell to system.
This symposium was organized to present research dealing with the effects of intermittent hypoxia on cardiorespiratory systems and cellular mechanisms. The pattern of neural impulse activity has been shown to be critical in the induction of genes in neuronal cells and involves distinct signaling pathways. Mechanisms associated with different patterns of intermittent hypoxia might share similar ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.18214